ceesdekker.net Secrets
ceesdekker.net Secrets
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Applying one-molecule optical and AFM imaging and power-spectroscopy methods, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our study pursuits involve:
It had been only in the nineties though, when nanotechnology had Highly developed to some amount in which one molecules might be manipulated, that the main experimental gadgets started to look.
, Groningen researchers current the outcome in their initiatives for making labs extra sustainable and supply tips for other labs.
Since 2000, Dekker has shifted the key aim of his function in direction of biophysics where by he research the Homes of one biomolecules and cells utilizing the tools of nanotechnology. This variation of subject was pushed by his fascination for the exceptional operating of Organic molecular buildings, and through the very long-time period perspective that many intriguing discoveries might be predicted During this industry.[five] Current lines of study in his biophysics group are within the areas of:[6]
2015, discovery that condensin can be a very flexible protein composition; and initially detection of DNA knots making use of nanopores
Case in point (3) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim of your pore is highlighted in purple, along with a 3D rendering of your movement from the DNA rod is exhibited.
We shape microbes into kinds that deviate from their natural phenotype. Specially, I will clearly show our capability to condition Dwell E. coli microbes into novel designs which include rectangles, squares, triangles and circles.
He also found time to write numerous textbooks, send out Pretty much forty thousand tweets and lead a successful study group at Delft College of Know-how. ‘It doesn’t experience like function’, he states. ‘I’m just terribly curious.’
In 1993, like a younger and eager associate professor at Delft University of Engineering, I had originally targeted the analysis attempts of my group on measuring the electrical conductance of just one conducting-polymer molecule. Inside of two a long time, we had produced a device by which a single wire of a phthalocyaninepolysiloxane polymer was related concerning two intently spaced steel nanoelectrodes.
Resolving the step size in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process
‘The idea that There is certainly this type of matter to be a beginning, a large bang, is presently a fascinating signpost to look at that there was a creator. But more usually, and on the basis of pure rationality, I also arrive at a Christian interpretation of fact. An atheistic worldview is often a naturalistic worldview: essentially, there are only atoms and natural forces that we are able to measure.
2006, initial demonstration of molecular sorting in the lab with a chip utilizing biomotors; discovery of nanobubbles in reliable-point out nanopores; and to start with estimate of electrokinetic Vitality conversion in the nanofluidic channel
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes
Reliable-condition nanopores have established to get a incredibly adaptable probe cees dekker for solitary-molecule Investigation of DNA. I'll describe a few of our current findings – particularly DNA knots – as well as our efforts to expand the abilities of reliable-condition nanopores even more, inside the path of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.